Abstract
Wyosine [4,9-dihydro-4,6-dimethyl-9-oxo-3-(beta-D-ribofuranosyl) imidazo [1,2-a] purine], a component of tRNA, is known to be constrained in a solution in anti conformation around the glycosylic bond. Guanosine, when substituted with a bulky electronegative group at C8, position analogous to C2 of wyosine, assumes syn conformation. The conformation arrangements of wyosine 2',3',5'-triacetate 1 and its analogs C2 substituted with electronegative groups methoxy, benzyloxy and oxo were studied by diverse 1H NMR techniques. For C2 substituted congeners, significant increase in the North conformer population of sugar moiety was found. It was accompanied by an increase of the tg rotamer contribution at the expense of the gg one. Only in 3 the preferred segment of the anti region was changed and oriented towards high-syn.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
