Abstract
Conformational equilibria in 2-Et-2-Me- and 2-i-Pr-2-Me-1,3-dithians were followed by means of the chemical shifts of the 2-methyl groups. In comparison with the geminal methyl group an ethyl group slightly favours the axial position whereas an isopropyl group prefers the equatorial orientation. The change of J 27 in 2-i-Pr-1,3-dithian with temperature showed that the gauche rotamer, i.e. the i-Pr methine proton and the H-2 in a gauche relationship is thermodynamically more stable than the anti rotamer by about 0.15 kcal/mole.
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