Abstract
The major urinary metabolite of the most commonly abused psychotropic drug, Δ 9-tetrahydrocannabiol, is 11-nor-Δ 9-tetrahydrocannabiol-9-carboxylic acid (THC-COOH). With basic hydrolysis, extraction and concentration, this compound can easily be determined using micellar electrokinetic capillary chromatography with on-column multi-wavelength detection. After solid-phase extraction of 5 ml of urine, drug concentrations down to about 10ng/ml can be unambiguously monitored. Peak assignment is achieved through comparison of the retention time and absorption spectrum of the eluting THCCOOH peak with those of computer-stored model runs. The effectiveness of the approach is demostrated with data obtained from urine samples from different patients which tested positively for cannabinoids using a flourescene polarization immunoassay.
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