Abstract
During the last 15 years, evidence has accumulated indicating that the “active” processes underlying the phenomenon of nervous conduction in the myelinated fiber are localized at the nodes of Ranvier of the fiber. The myelin sheath is a thick membrane which apparently hinders a rapid exchange of ions between the axoplasm and the surrounding medium, and in consequence the nerve fiber responds to stimuli, coming either from outside or from the neighboring active region of the same fiber, only at the nodes where the surface membrane of the fiber is much thinner. We shall first summarize the experimental facts supporting this conclusion.
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