Complementary Therapies in Medicine | VOL. 54
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Concomitant botanical medicine use among patients participating in commercial prostate cancer trials.

Publication Date Aug 29, 2020

Abstract

Abstract Objectives Patients with cancer frequently use botanical medications. The concomitant use of such medications by patients on commercial trials has not been well-described, despite the importance of these trials for evaluating the safety and efficacy of new agents. We sought to describe the use of botanical medications taken by patients with prostate cancer enrolled on global commercial trials. Design Retrospective study. Setting Regulatory repository of commercial clinical trial data. Interventions Anti-cancer therapy. Main outcome measures Botanical and medication use data were pooled across six international commercial randomized trials for metastatic prostate cancer with detailed information on medication and indications. Botanical products were considered to have potential for drug interaction if they led to a change in drug exposure in human trials. Potential for interaction was ascertained by PubMed review. Descriptive statistics were used for analysis. Results Of 7318 enrolled patients, 700 (10 %) reported botanical use at any time and 653 (9%) reported use of botanical products while on trial. Nearly half of botanical product types were not classified by plant (43 %). The highest proportion of botanical use was among patients in Asian countries (32 %), followed by patients in North America (13 %). Eighty-six different types of botanical products were used; of these, nineteen had a patient-reported anti-cancer indication. Conclusions Botanical medicine use among patients with prostate cancer in commercial tri...

Concepts
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Commercial Trials
Botanical
Concomitant Use
Use Of Botanical Products
Patients In Asian Countries
Change In Drug Exposure
Use Of Such Medications
Prostate Cancer
Prostate
Human Trials

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