Abstract
AbstractA concise route for the synthesis of the novel compound class tetrazoleâdiketopiperazines was developed. The approach involves the use of two multicomponent reactions: the Ugi tetrazole fourâcomponent reaction (4CR) and the classical intramolecular Ugi 4CR. The tetrazoleâdiketopiperazines comprise analogs of and are bioisosteric to bioactive diketopiperazines, which thus draws attention for novel bioactive compound design. This scaffold was produced to fill the screening deck of the European lead factory.
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