Concise Communications: �Death of a Patient Aged 2.5 Years after Infection Cause Parainfluenza Virus Type 1�

Abstract

Introduction: In this study we describe the identification of parainfluenzae virus (PIV) type 1 as the etiological agent of bronchopneumonia and cardio-respiratory failure which caused the death of a child aged of 2.5 years. The objective of the study was to show the possibility that infection with PIV 1 can causes death. Case presentation: The patient had the diagnosis of SARI (Severe Acute Respiratory Infection) at the admission in the hospital, but few hours after the hospitalization, she died. Laboratory tests were within normal limits (total WBC and differential, serum immunoglobulins, liver transaminases, urinalysis, blood sedimentation rate) and the patient showed no associated diseases. We before tested the sample (fragment of the right lung) for the presence of influenza virus type A and B (including pandemic H1N1), because the patient became ill in the pandemic season 2009-2010. After that the detection of influenza viruses was negative, we tested the sample for the presence of the others respiratory viruses. In the same time, we tested if the specimen had the respiratory bacteria associated with. The Real-time PCR method for detection of A/H1N1 pandemic virus and the Reverse Transcription-Polymerase Chain Reaction (RT-PCR) for detection of other non-influenza viruses (respiratory syncytial virus, human metapneumo virus, PIV 1, 2 and 3, Coronaviruses 229E and OC43) were used as diagnostic methods. In the same time, the Kit RV/PB18 ASE Detection (Seegene) was used in order to test a potential bacterial etiology of the infection (Streptococcus pneumoniae, Haemophilus influenzae, Legionella pneumophila, Mycoplasma pneumoniae, Chlamydophila pneumoniae). Conclusion: Finding of this study is that although the patient has no experienced chronic diseases associated with, she died from a bronchopneumonia caused by PIV type1.