Abstract
Two different tracheobronchial (TB) morphologies are compared for suitability of representing the human when assessing the fate of inhaled particulate matter. Aerosol behavior within the branching networks is described by theoretical deposition probability equations. Computations using a symmetric TB morphology are in very good agreement with experimental measurements of aerosol deposition from inhalation exposure tests using human subjects. Computer model calculations using an asymmetric TB pattern consistently estimate lower doses delivered to human airways. Findings suggest the symmetric TB morphology computer model may be used as an aid in aerosol therapy by identifying the effects of patient breathing rates and medicinal aerosol sizes upon the dispersion of therapeutic agents within the respiratory tract.
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