Abstract
BackgroundThe diagnostic evidence of gastritis cystica profunda (GCP) are not adequately described due to its extremely low morbidity. This study aimed to analyze and summarize the comprehensive CT features and clinical characteristics of patients with GCP.ResultsNineteen patients were enrolled, including eight men and eleven women, with a mean age of 55.53 years. Only one patient had the history of gastric polypectomy. Among the nineteen cases, two cases were in the gastric cardia, four in the gastric fundus, eight in the gastric body and five in the gastric antrum. The shapes were sphere in thirteen patients, hemisphere in five patients and diffuse in one patient. The mean size of eighteen local lesions was 1.63 cm. The cystic changes in submucosa were detected in fifteen patients. Compared with the pancreas, most GCP lesions were hypo-attenuated on unenhanced CT (n = 8), in arterial phase (AP) (n = 17) and venous phase (VP) (n = 11). Fifteen patients had the peak enhancement in VP and two in AP. The rim-like enhancement with central low attenuation was clearly observed in thirteen patients. For the GCP accompanied by adenocarcinoma, the enhancement peak was present in AP and the gradual expansion of enhancement area was in VP. All patients underwent surgical or endoscopic resection. Sixteen cases had remission of symptoms and no recurrence.ConclusionsThe careful analysis of CT features and clinical characteristics can provide support for deepening the understanding of the GCP. However, a more accurate diagnosis depends on histopathological features.
Highlights
The diagnostic evidence of gastritis cystica profunda (GCP) are not adequately described due to its extremely low morbidity
Laboratory findings showed that tumor markers (CEA, alpha fetoprotein (AFP), carbohydrate antigen 125 (CA125) and carbohydrate antigen 199 (CA199)) were unremarkable
Operations were performed in all nineteen patients, including total gastrectomy (n = 1), subtotal gastrectomy (n = 3), endoscopic mucosal resection (EMR) (n = 7) and endoscopic submucosal dissection (ESD) (n = 8)
Summary
The diagnostic evidence of gastritis cystica profunda (GCP) are not adequately described due to its extremely low morbidity. This study aimed to analyze and summarize the comprehensive CT features and clinical characteristics of patients with GCP. Gastritis cystica profunda (GCP) is a relatively rare disease characterized by hyperplasia and cystic dilation of gastric glands involving the submucosal layer or even muscularis propria of the stomach [1]. For the patients with unoperated stomach, widespread chronic active/atrophic gastritis are considered as an important factor leading to. GCP is more likely to be underdiagnosed as the result of unremarkable clinical characteristics and nonspecific imaging manifestations. GCP has been considered to be a possible premalignant lesion in several reports [5,6,7,8]. Accurate diagnosis of GCP is very useful for the development of individualized treatment strategies
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