Abstract
Underwater adhesion in mussels (Bivalvia) is an extreme adaptation to achieve robust and firm wet adhesion in the freshwater/brackish/ocean, which biochemically shaped through millions of years. The protein-based adhesion has huge prospective in various fields like industry, medical, etc. Currently, no comprehensive records related to the systematic documentation of structural and functional properties of Mussel foot proteins (Mfps). In this study, we identified the nine species of bivalves in which the complete sequence of at least one adhesive protein is known. The insilico characterization revealed the specific physio-chemical structural and functional characters of each Mfps. The evolutionary analyses of selected bivalves are mainly based on Mfps, Mitogenome, and TimeTree. The outcome of the works has great applications for designing biomimetic materials in future.
Highlights
Some groups of mussels are capable to produce proteinaceous glue- like sticky material known as byssus thread made by an array of foot proteins
A total of 78 Mussel foot proteins (Mfps) are available in NCBI protein bank
This is the first report by using the insilico methods to evaluate the physiochemical structural and functional characterization of all available Mfps revealed the unique characteristic features of each mussel foot proteins (Mfps)
Summary
Some groups of mussels are capable to produce proteinaceous glue- like sticky material known as byssus thread made by an array of foot proteins (fps). This byssus contains mainly four parts i.e. Plaque, thread, stem, and root. Each part of the byssus thread complex formed by the auto-assembly of secretory products originating from four distinct glands enclosed in the mussel foot[4,5] These mussel foot protein (Mfps), mastered the ability to binding the diverse substratum by using adhesive plaques. Designing of mussel-mimetic adhesive materials, initially we need to understand the specific physio-chemical and functional property of each Mfps This works aims to divulge the physio-chemical structural and functional characterization of currently available all Mfps of various species. The structural modeling and functional analysis of Mfps helps to understanding the which Mfps is highly promising for specific industrial and therapeutical applications
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