Abstract
AbstractSemaphorin family members (Semaphorins; SEMAs) consist of a large family that includes both secreted and membrane‐associated proteins that are originally found to provide axon guidance in selected areas for neural development. The SEMAs have diverse biologic activities such as neuronal cellular migration, axon guidance, vasculogenesis, branching morphogenesis, and cardiac organogenesis. Recent studies have reported that SEMAs also play crucial roles in various carcinomas. However, the association and their role in oral squamous cell carcinoma (OSCC) are still poorly understood. In this study, we evaluated SEMAs mRNA expression in OSCC‐derived cell lines using quantitative reverse transcriptase‐polymerase chain reaction (qRT‐PCR) analysis and revealed the altered gene expression profile of the SEMAs in OSCC cell lines compared with human normal oral keratinocytes. We found that tendency for up‐regulation of SEMA3E, 4C, 5A, 6B, and 7A in OSCC‐derived cell lines. Especially, SEMA3E and SEMA7A mRNA were significantly up‐regulated in all OSCC‐derived cell lines. On the other hands, SEMA3A, 3C, 3F, and 6A mRNA were significantly down‐regulated in all OSCC‐derived cell lines. The expression and role of SEMAs in OSCC depend on the forms and may provide novel insights and therapeutic target for OSCCs.
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