Abstract
Type 2 diabetes mellitus (T2DM) is a metabolic disorder disease. Traditional Chinese Medicine (TCM) has a long history for treatment of T2DM. The TCM herb treatments effectively elevate the visceral functions of human body, adjust the inner body environment, balance the level of blood glucose, and cause less side effects. We aim to find core TCM herbs in the treatments of T2DM and discover the underlying mechanism of core herbs in treating T2DM. The prescriptions and herbs upon TCM for treating T2DM was searched in literatures and the complex network was constructed to find the core herbs. After selecting the core herbs, molecular docking was performed to find interactions between compounds of the core herb and related receptors by using LigandFit and CDocker. The results of the literature study shown that Milkvetch Root [Astragalus membranous (Fisch) Bunge, HQ, Huangqi in Chinese pinyin] was the most commonly used herb in treating T2DM. Molecular docking results shown that the compounds of HQ have comparatively interactions with the diabetes related receptors. According to the results, four compounds have interactions with peroxisome proliferator activated receptor (PPAR-γ), six compounds have interactions with dipeptidyl peptidase-IV (DPP-IV), and two compounds have interactions with Glycogen phosphorylase (GP). These results suggest that HQ can play a key role in the metabolism of human glucose and has a complex mechanism with the characteristic of multi-components and multi-targets in the treatment of T2DM.
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