Abstract
The action of compound 48/80 (a mixture of condensation products of p-methoxy- N-methylphenethylamine with formaldehyde) on liposomal membranes was studied by means of K +-loaded liposomes and a K + ion-selective electrode. Prompt efflux of K + was detected when 48/80 was added to the negatively charged liposome suspension, while the monomer of 48/80, p-methoxy- N-methylphenethylamine, did not release K + from the same liposomes. The mechanism for the action of 48/80 is discussed in comparison with that of a polymyxin, well known as an antibiotic acting on bacterial membranes.
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