Abstract
In this study, the essential oil (EO) constituents from the aerial parts of Satureja intermedia C.A.Mey were detected by GC and GC/MS. The antimicrobial activity of EO on oral pathogens and its cytotoxicity to human cancer cells were determined by the microbroth dilution method and the crystal violet staining method, respectively. Thirty-nine compounds were identified and the main EO constituents were γ-terpinene (37.1%), thymol (30.2%), p-cymene (16.2%), limonene (3.9%), α-terpinene (3.3%), myrcene (2.5%), germacrene B (1.4%), elemicine (1.1%) and carvacrol (0.5%). The S. intermedia EO showed a concentration-dependent decrease in viability of Hep-G2 (hepatocellular carcinoma) and MCF-7 (breast adenocarcinoma) human cancer cell lines (p < 0.05). Antimicrobial screening of S. intermedia EO demonstrated slight antibacterial and antifungal activities against Streptococcus mutants, S. salivarius, Enterococcus faecalis, Staphylococcus aureus, Candida albicans and C. glabrata. Further preclinical studies are needed to assess the efficacy and safety of S. intermedia EO as a new promising anticancer agent.
Highlights
Nowadays, many classes of synthetic pharmaceuticals are prescribed in conventional medicine for disease treatment and management
The essential oil (EO) constituents from the aerial parts of Satureja intermedia C.A.Mey were detected, and the antimicrobial and cytotoxic activities of EO were determined on oral pathogens and human cancer cells, respectively
Antimicrobial activity of the S. intermedia EO was assayed on oral pathogens including: Streptococcus mutants (ATCC 25175, ATCC 31383 and ATCC 35668), Streptococcus salivarius (ATCC 13419 and ATCC 9222), Enterococcus faecalis (ATCC 29212 and ATCC 11700), Staphylococcus aureus (ATCC 25923 and ATCC 700698), Candida albicans (ATCC 13803 and ATCC 10261) and C. glabrata (ATCC 2001 and ATCC 90030) were determined
Summary
Many classes of synthetic pharmaceuticals are prescribed in conventional medicine for disease treatment and management. The emergence of antibiotic resistance and multidrug resistance in microbial and cancer cells, respectively, may seriously threaten the success of conventional therapies, opening a new and alternative scenario which arises from the traditional herbal medicines [14,15,16,17,18,19,20]. The aerial parts of Satureja species have a typical taste and can be added to meat, pies, stuffing and sausages as a spice. The EO constituents from the aerial parts of Satureja intermedia C.A.Mey were detected, and the antimicrobial and cytotoxic activities of EO were determined on oral pathogens and human cancer cells, respectively
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
