Abstract
Numerous processing techniques aim to impart interconnected, porous structures within regenerative medicine materials to support cell delivery and direct tissue growth. Many of these techniques lack predictable control of scaffold architecture, and rapid prototyping methods are often limited by time-consuming, layer-by-layer fabrication of micro-features. Bicontinuous interfacially jammed emulsion gels (bijels) offer a robust, self-assembly-based platform for synthesizing a new class of morphologically unique cell delivery biomaterials. Bijels form via kinetic arrest of temperature-driven spinodal decomposition in partially miscible binary liquid systems. These non-equilibrium soft materials are comprised of co-continuous, fully percolating, non-constricting liquid domains separated by a nanoparticle monolayer. Through the selective introduction of biocompatible precursors, hydrogel scaffolds displaying the morphological characteristics of the parent bijel can be formed. We report using bijel templating to generate structurally unique, fibrin-loaded polyethylene glycol hydrogel composites. Demonstration of composite bijel-templated hydrogels (CBiTHs) as a new cell delivery system was carried out in vitro using fluorescence-based tracking of cells delivered to previously acellular fibrin gels. Imaging analysis confirmed repeatable delivery of normal human dermal fibroblasts to acellular fibrin gels.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
