Abstract
Carbapenemase-producing Klebsiella pneumoniae is an important opportunistic pathogen due to its drug resistance. This study reports on the isolation and characterization of a podophage, named Pylas, infecting this bacterium. The complete genome of phage Pylas is described, and it is distantly related to the well-studied phage N4.
Highlights
Multidrug-resistant Klebsiella pneumoniae poses an urgent threat to public health due to its ability to infect patients with a compromised immune system [1, 2]
Similar to N4, the Pylas genome has direct terminal repeats, which were predicted by PhageTerm [17] to be 769 bp long; the Pylas genome is generally syntenic with N4
Pylas is closely related to Klebsiella phage KpCHEMY26
Summary
Multidrug-resistant Klebsiella pneumoniae poses an urgent threat to public health due to its ability to infect patients with a compromised immune system [1, 2]. Phage Pylas was assembled at 79.6-fold coverage into a unit genome of 70,408 bp [17]. The GC content of Pylas is 41%, in contrast to the 57% GC content of its Klebsiella host [18]. As determined by BLASTp, Pylas shares 30 proteins with Escherichia coli
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