Abstract
ABSTRACTCarbapenems are considered last-resort antibiotics used to treat human infections caused by multidrug-resistant bacteria. In 2011, VIM-1 carbapenemase-producing Salmonella enterica subsp. enterica serovar Infantis strains were isolated from livestock for the first time in Germany. Here, we announce the complete genome sequence of the first German blaVIM-1-harboring Salmonella Infantis isolate (15-SA01028) originating from food.
Highlights
Carbapenems are considered last-resort antibiotics used to treat human infections caused by multidrug-resistant bacteria
Subsequent whole-genome sequencing (WGS) using Illumina MiSeq technology and S1-pulsed-field gel electrophoresis (S1-PFGE) hybridization of the respective isolate revealed that the isolate harbored a pRH-R27-like plasmid carrying a blaVIM-1-encoding carbapenemase [2]
Genome sequencing was performed by GATC Biotech AG (Constance, Germany) using the PacBio RS II system
Summary
Carbapenems are considered last-resort antibiotics used to treat human infections caused by multidrug-resistant bacteria. Subsequent whole-genome sequencing (WGS) using Illumina MiSeq technology and S1-pulsed-field gel electrophoresis (S1-PFGE) hybridization of the respective isolate revealed that the isolate harbored a pRH-R27-like plasmid carrying a blaVIM-1-encoding carbapenemase [2]. To understand the microevolution of the blaVIM-1-carrying plasmid and its transmission routes along the German food production system, the isolate was further subjected to PacBio RS II long-read sequencing.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
