Abstract
A novel papillomavirus (PV) was detected in farmed wels catfish (Silurus glanis) in Hungary showing clinical signs resembling those of wels catfish herpesvirus disease. The whole genome of Silurus glanis papillomavirus 1 (SgPV1) was identified using next-generation sequencing. The 5,612-bp complete genome contains four predicted protein coding regions (E1, E2, L1, and L2), which seem to have homologues in every PV genome sequenced to date. Five complete fish PV genome sequences are available in the GenBank database. Their genomes range between 5,748 and 6,086 bp and contain the minimal PV backbone genes E1, E2, L2, and L1, unlike PVs of higher vertebrates, which have larger genomes (6.8-8.6 kbp) and additional (onco)genes. Considering the current species demarcation criteria for the family Papillomaviridae, the establishment of a novel species named "Nunpapillomavirus siluri" is proposed for the SgPV1 in a novel genus, "Nunpapillomavirus", in the subfamily Secondpapillomavirinae.
Highlights
Papillomaviruses (PVs) are small (55 nm in diameter), icosahedral, non-enveloped viruses with circular, doublestranded DNA
All known PVs belong to the family Papillomaviridae, and their classification is based on pairwise nucleotide sequence identity in the major capsid protein (L1) gene
In the subfamily Firstpapillomavirinae, there are more than 50 genera with over 130 species recognized by the International Committee on Taxonomy of Viruses (ICTV), with all of their members originating from higher vertebrates [10]
Summary
Papillomaviruses (PVs) are small (55 nm in diameter), icosahedral, non-enveloped viruses with circular, doublestranded DNA. All known PVs belong to the family Papillomaviridae, and their classification is based on pairwise nucleotide sequence identity in the major capsid protein (L1) gene. The whole genome of the associated lymphocystivirus (LCDV) was identified by next-generation sequencing, and the first fish PV and a novel polyomavirus (PyV) were discovered [5].
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