Abstract
The novel infectious bursal disease virus (IBDV) isolate BGE14/ABT1/MVC/India is a very virulent IBDV that was isolated from broiler flocks in southern parts of India during 2014. Here, we report, for the first time in India, the complete genome sequence of BGE14/ABT1/MVC/India, a reassortment strain with segments A and B derived from a very virulent IBDV strain and an attenuated IBDV, respectively. The findings from this study provide additional insight into the genetic exchange between attenuated and very virulent strains of IBDV circulating in the field.
Highlights
Infectious bursal disease (IBD) is a highly contagious disease of young chickens caused by IBD virus (IBDV) belonging to the Birnaviridae family [1]
Coinfection with very virulent IBDV and attenuated IBDV strains has led to the exchange of double-stranded genomic RNA segments to generate new reassortment viruses [3,4,5]
The presence of IBDV was diagnosed by agar gel immunodiffusion using specific hyperimmune serum and reverse transcriptase (RT)-PCR by amplifying the VP2 hypervariable region [6]
Summary
Infectious bursal disease (IBD) is a highly contagious disease of young chickens caused by IBD virus (IBDV) belonging to the Birnaviridae family [1]. In the pathogenic serotype I, the large genomic segment A encodes for four viral proteins, the two capsid proteins VP2 (48 kDa) and VP3 (32 to 35 kDa), the viral protease VP4 (24 kDa), and a nonstructural protein VP5 (17 to 21 kDa). Coinfection with very virulent IBDV (vvIBDV) and attenuated IBDV strains has led to the exchange of double-stranded genomic RNA segments to generate new reassortment viruses [3,4,5].
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