Abstract
Differential scanning calorimetry (DSC) with the support of Fourier transform infrared spectroscopy (FT-IR) was used as a screening technique for testing the compatibility of piroxicam (4-hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3carboxamide-1,1-dioxide) with various pharmaceutical excipients for solid dosage forms. Based on the results, magnesium stearate, stearic acid, and mannitol were found to show interaction with piroxicam. In conclusion, tools of DSC and FT-IR were successfully employed to evaluate the compatibility of piroxicam and selected excipients.
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