Abstract
Inthis study, the effects ofAloe vera gel and coconut oil onwound healing were investigated and compared inrats. Forty-two Wistar albino rats were used during the experiment, inwhich they were operated onunder general anaesthesia tocreate two full-thickness open skin wounds (created with a 0.5cm diameter punch biopsy apparatus) onboth back sides of the median line. Atotal of42rats were divided into three groups of14animals each toreceive the topical application ofAloe vera gel (AVgroup- n=14), coconut oil (COgroup- n=14) and cold cream (CONT group- n=14). The medical applications were performed twice aday inall thegroups. Thewound borders were marked onatransparent sheet every day. Afterwards, this sheet was transferred tothemillimetre graph paper. Ondays0, 7, and 14, the unhealed wound area was measured inall the groups. Ondays7 and 14, seven rats ineach group were euthanised. Then, skin samples including the intact skin were taken from the wound sites for histopathological and biochemical evaluations. The topical application ofAloe vera gel showed asignificant increase inthe healing process oftheopen wounds interms ofthe clinical evaluation, histopathological and biochemical data averages when compared with the coconut oil and cold cream groups ofrats (P<0.05). The results obtained inthe present study demonstrate that Aloe vera gel may provide agood alternative for thetreatment ofopen wounds.
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