Abstract
Comparison of two immunoassays for CA19-9, CEA and AFP tumor markers
Highlights
Monoclonal antibodies are used to detect serum antigens associated with specific malignancies
The highest deviation from the declared control values was found for CA19-9 on Vitros ECi and for AFP on Cobas e411 analyzer
High correlation was found between methods for all of three tumor markers studied (R = 0.978 for CA19-9; R = 0.995 for Carcinoembryonic antigen (CEA) and R = 0.999 for AFP)
Summary
Monoclonal antibodies are used to detect serum antigens associated with specific malignancies. These tumor markers are most useful for monitoring response to therapy and detecting early relapse, but results obtained by different assays vary, and a change of method during follow-up may cause problems. Tumor markers are used for the cancer risk estimation, early detection of the disease, screening, diagnosis, prognosis, prediction of therapy success and detecting the recurrence or monitoring progression of the disease. CEA was detected in the circulation of patients and recognized as a serum marker for colorectal cancer This tumor marker has not been advocated as a screening test for colorectal cancer; a preoperative CEA serum level is useful for diagnosis and prognosis of recurrence and survival in colorectal cancer patients. The levels of CEA increased with increasing tumor stage [2,3]
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