Abstract
Introduction Finding a more simple and low risk approach for chorion villus sampling (CVS) can improve our ability to develop this method and will increase the clinicians and patients utilization for prenatal diagnosis. Methods Women were continuously assigned transvaginal–transamyometrial (TVTM) chorionic villus sampling (CVS) and transcervical (TC) CVS in a quasi-experimental study. Results Data from 244 consecutive cases following prenatal diagnosis by transcervical (TC) CVS ( n=104) and transvaginal–transmyometrial (TVTM) CVS ( n=140) were evaluated. Fetal loss before 28 weeks of gestation took place in four cases (1.6%) of TC-CVS and in three cases (1.2%) of TVTM-CVS. Rate of spotting after CVS was 3.3% for TC and 2.5% for TVTM. Conclusions We believe that TVTM-CVS is a simple, safe and effective technique for prenatal diagnosis of genetic diseases. We recommend TVTM CVS procedure as the first choice for prenatal diagnosis.
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