Abstract
The safety of reproductive nuclear transfer (or mitochondrial replacement therapy) in cases of IVF in patients with severe forms of infertility or a family history of mitochondrial diseases causes lively debate worldwide. Meanwhile, births of 13 children following this technique have already been announced. However, while the safety of the artificially created mitochondrial heteroplasmy is being discussed, the issue of possible induction of chromosomal abnormalities in the embryos caused by the manipulations with the nuclei at the stage of reconstruction is not addressed.
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