Abstract
Introduction: There are 4 groups of LPs divided according to the mechanism of action. They act on the brain by modulating monoaminergic systems, causing a series of side effects such as insomnia, sedation, anxiety, and a problem of a sexual nature. By appropriately selecting the drug and its dose, the negative effects of the therapy can be avoided.Aim : Comparison of the mode of action of a drug from a given group of antidepressants and description of its side effects.State of knowledge : An example from the first group of drugs with a receptor mechanism of action is trazodone - it acts on many receptors. The combined effect of the drug on all three receptors will significantly improve sleep in all its phases. It is as effective a drug as TLPD, and due to the lack of anticholinergic and cardiotoxic effects, it has a better tolerance and safety profile. It works quickly and improves sleep parameters, which is responsible for faster improvement of the patient's mental state. An example of a drug from the second group of drugs with a different mechanism of action is agomelatine. It is a synthetic analog of melatonin. The simultaneous agonist action on one receptors and antagonist action on the other causes a number of changes in the CNS, which are responsible for the antidepressant effect. The effects of the treatment can be seen after 2 weeks of use. The drug of the third groupneurotransmitter reuptake inhibitorsthere is bupropion. It intensifies the dopaminergic transmission. It does not disturb the sexual sphere, but increases insomnia as a side effect.Summary : By selecting the appropriate LP and its dose, side effects can be avoided.
Highlights
There are 4 groups of LPs divided according to the mechanism of action
[1] The monoaminergic systems and their neurotransmitters: noradrenaline, serotonin, dopamine played a great role in the development of pharmacotherapy of central nervous system diseases
The observation that these drugs relieve the symptoms of the disease in most depressed patients gave rise to the monoaminergic hypothesis of depression, which assumed that the disease was caused by deficits in neurotransmitters in synapses
Summary
There are 4 groups of LPs divided according to the mechanism of action They act on the brain by modulating monoaminergic systems, causing a series of side effects such as insomnia, sedation, anxiety, and a problem of a sexual nature. State of knowledge : An example from the first group of drugs with a receptor mechanism of action is trazodone - it acts on many receptors. An example of a drug from the second group of drugs with a different mechanism of action is agomelatine. Over the past 60 years, different categories of antidepressant drugs (LPs) have emerged, the first of which were discovered by chance They all act on the brain by modulating monoaminergic systems. Noxiptiline A four-ring (tetracyclic) antidepressant drug - noradrenaline reuptake inhibitor - e.g. maprotiline Serotonin and norepinephrine reuptake inhibitors (SNRI) - e.g. venlafaxine.
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