Abstract
The lens proteins from three lines of congenic mice which are homozygous for the gene retinal degeneration ( rd) or retinal degeneration slow ( rds) or carrying the normal alleles (normal) were analyzed by SDS-PAGE and by immunological reactivity to specific monoclonal antibodies. The lens proteins of normal, rd, and rds mice showed a similar developmental pattern between postnatal day 0 and postnatal day 30. The expression of the 25000 molecular weight (MW) β-crystallin polypeptide which appears postnatally in the normal lens was not affected by retinal abnormalities in the mutant mice. It is concluded that the regulation of the 25000 MW β-crystallin polypeptide is not dependent upon differentiation or maintenance of the photo-receptor outer segments or continued presence of the photoreceptor cells.
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