Abstract
The magnitude of the starve-refeed response and the effect of dietary fructose on the activities of hepatic glucose 6-phosphates dehydrogenase (G6PD) and malic enzyme (ME) were studied. The magnitude of increase in enzyme activity was similar in rats starved and refed the glucose diet or fed the fructose diet ad libitum when compared to rats fed the glucose diet ad libitum . In rats starved and refed the fructose diet, the starve-refeed response and the fructose effect were additive, suggesting that the two responses have different mechanisms. When the enzyme response to a subsequent starve-refeed episode was studied it was found that a previous starve-refeed episode increased the subsequent response to starvation-refeeding, whereas prefeeding the fructose diet ad libitum did not. Both the starve-refeed response and the fructose effect were inhibited by 8-azaguanine, suggesting a requirement for de novo RNA synthesis. The data suggest that the nature of requirement for de novo RNA synthesis is different in the starve-refeed response from the requirement for de novo RNA synthesis for the fructose effect.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
