Abstract
Comparison of the Expression Intensity of Estrogen Receptor Marker in Oral and Cutaneous Pemphigus Vulgaris
Highlights
Rahrotaban S,et al Introduction: Pemphigus vulgaris (PV) belongs to the category of blistering diseases and affects both skin and mucous membranes. It involves the autoantibodies against cell surfaces of keratinocytes, and causes acantholysis and blistering.[1,2] PV is considered an autoimmune disease, based on the production of autoantibodies such as IgG and IgA against intercellular attachments known as desmosomes.[1, 2]
Some researchers have reported that ERα is mostly found in classical target tissues of estrogen such as the mammary gland and endometrium, while ERβ can be found in tissues such as colon and prostate epithelium.[8]. Valimaa et al reported that ERα was absent in the buccal mucosa, gingiva and salivary glands, whereas ERβ was found in keratinocytes and acinar and ductal portion of salivary glands
We investigated estrogen receptor (ER) expression in oral and skin lesions of PV, since ERs are present in different tissues such as the gingiva and epithelium, in addition to the classical target tissues, and some researchers believe that change in estrogen levels can cause changes in oral soft tissues
Summary
Pemphigus vulgaris (PV) belongs to the category of blistering diseases and affects both skin and mucous membranes. Some researchers have reported that ERα is mostly found in classical target tissues of estrogen such as the mammary gland and endometrium, while ERβ can be found in tissues such as colon and prostate epithelium.[8] Valimaa et al reported that ERα was absent in the buccal mucosa, gingiva and salivary glands, whereas ERβ was found in keratinocytes and acinar and ductal portion of salivary glands They concluded that estrogen can affect oral tissues via ERβ [8].
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