Comparison of The Effectiveness of Ethanol Extract and Infusion of Leaf of Binahong (Anredera Cordifolia Steen) as Antidiabetes In Male Rats Alloksan Induced

Abstract


 
 
 Anredera cordifolia Steen. contains flavonoids, saponins, steroids and alkaloids. Flavonoid compounds have the same indications as glibenclamide to lower blood glucose levels. Saponin compounds in binahong leaves can lower blood sugar and cholesterol levels. This study aims to determine the comparison of the antidiabetic effect and dose between the extract and infusion of binahong leaves on male Swiss strain mice induced by alloxan. This type of research uses experimental methods with pre and post test with the controlled group design. The test animals used in this study were 40 male Swiss strain mice which were divided into 8 groups. The negative control group was only given 0.5% CMC Na, the positive control group was given glibenclamide for comparison, the treatment group was given extract and infusion of binahong leaves at a dose of 35 mg/KgBW, 70 mg/KgBW, and 140 mg/KgBW. The results of this study showed that there were differences in blood sugar levels before and after alloxan induction (sigh<0.05). Binahong leaf extract and infusion had effectiveness as antidiabetic in alloxan-induced Swiss male mice with the results showing that the three doses had an antidiabetic effect and the first dose of 35mg/KgBB of the extract gave the maximum effect of 40.6%, while the infusion dose was 40.6%. III 140mg/KgBB has a maximum effect of 30.5%. So it can be concluded that there is a statistically significant difference in blood sugar levels in the extract and infusion groups of binahong leaves.