Abstract

Abstract Introduction: Research has shown that physical activity, especially aerobic exercise, has a protective role against oxidative liver damage, reducing inflammation, injury and liver fibrosis, and a review of some studies shows the destructive effects of methylphenidate on some organs; Therefore, the aim of this study was to compare the effect of aerobic exercise and methylphenidate on the antioxidant indices of liver tissue in male Wistar rats with attention deficit / hyperactivity disorder. Methods: The research method was laboratory. Thirty-six hyperactive male Wistar rats with mean and standard deviation of 186.23±7.32 were divided into 3 groups of 9 rat : endurance training, methylphenidate consumption, endurance training + methylphenidate consumption and a group of 9 rat. The experimental groups practiced for 6 weeks, 5 days a week and 60 minutes a day. One-way analysis of variance test was used to analyze the data. Results: The results showed that there was a significant difference between superoxide dismutase and catalase enzymes in the control group compared to other groups (ADHD without exercise and without methylphenidate, ADHD + aerobic exercise, ADHD + methylphenidate, ADHD + methylphenidate + aerobic exercise). Had (P≤0.001). Also, there is a significant difference between superoxide dismutase and catalase enzymes of ADHD group without aerobic exercise and without methylphenidate consumption compared to other groups (control, ADHD + aerobic exercise, ADHD + methylphenidate consumption, ADHD + methylphenidate consumption + aerobic exercise) (P≤0.001). But there was no significant difference between superoxide dismutase and catalase enzymes in ADHD + aerobic exercise group with ADHD + methylphenidate group and also with ADHD + methylphenidate + aerobic exercise group (p≥0.01). Conclusion: It seems that aerobic exercise can replace the use of methylphenidate in connection with superoxide dismutase and catalase enzymes in male Wistar rats with attention deficit / hyperactivity disorder.

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