Comparison of the clinical effects of heparin and bivalirudin on percutaneous coronary intervention in patients with acute coronary syndrome

Abstract

Objective To compare the efficacy of heparin and bivalirudin in patients with acute coronary syndrome undergoing emergency percutaneous coronary intervention (PCI). Methods A total of 90 patients with acute coronary syndrome were included in this study.They were divided into the study group and control group according to the requirements of random envelope method, 45 cases in each group.The study group received bivalirudin during PCI, the control group was given heparin.The Fbg, APTT, TT and PT were detected in the two groups, and the incidence of adverse reactions (heart failure, cardiac death, platelet reduction, hemorrhage of digestive tract) was analyzed. Results After treatment, there were no statistically significant differences between the two groups in various blood coagulation indicators (all P>0.05). The incidence rate of adverse events of the study group was 4.44%, which was significantly lower than 24.44% of the control group, and the difference was statistically significant (χ2=7.28, P<0.05). Conclusion Application of heparin and bivalirudin in PCI has similar efficacy, but the safety of bivalirudin is higher, which is worthy of clinical promotion. Key words: Acute coronary syndrome; Heparin; Bivalirudin