Abstract
In this study, ferulic acid (FA) was covalently bound to one of the primary hydroxyls of β-cyclodextrin (β-CD) via an ester linkage to improve its stability and biological activity. Experiments using UV, FTIR, FS, NMR, MS and FE-SEM were performed to characterize the structure of the FA-β-CD conjugate. Physicochemical properties such as solubility, crystallinity, thermal stability and photo-stability of the conjugate were also investigated, and the results revealed that the conjugate was in an amorphous form with improved thermal stability and photostability compared with the FA/β-CD inclusion complex. Furthermore, in vitro cytotoxicity of the FA-β-CD conjugate against HepG2 cell was enhanced with effective growth inhibition. Taken together, the present study indicates that the FA-β-CD conjugate might be a novel and potential functional composition for application in food and medicine.
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