Abstract
While cell cycle markers have been used to differentiate benign versus malignant lesions and to classify malignant lesions, benign keratoses have not been well studied using such markers, and the relation of the cell cycle to inflammation or irritation of benign keratoses is unclear. We compared the immunohistochemical staining patterns of 10 seborrheic keratoses, 10 inflamed seborrheic keratoses, and 10 inverted follicular keratoses using antibodies to p53, bcl‐1, and bcl‐2. Staining with antibodies to p53 was increased in inverted follicular keratoses compared to inflamed or non‐inflamed seborrheic keratoses. Bcl‐1 staining was similar in all lesions. A population of bcl‐2‐positive dendritic cells was seen within the epidermal portion of inverted follicular keratoses. Keratinocyte bcl‐2 staining was higher in seborrheic keratoses compared to the other two keratoses. Bcl‐2 may be increased in seborrheic keratoses as an anti‐apoptotic mechanism while increased p53 may trigger apoptosis in inverted follicular keratoses.
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