Comparison of recovery profiles of propofol and sevoflurane anesthesia with bispectral Index monitoring In general anesthesia: Running title: Recovery profiles: Propofol vs sevoflurane

Abstract

Introduction: Introduction of more rapid and short-acting volatile anesthetics and intravenous anesthetics has allowed anesthesiologists to achieve a recovery profile that facilitates rapid emergence after general anesthesia. Both propofol and sevoflurane provide rapid induction and faster recovery by titrating the depth of anesthesia based on the BIS Index during maintenance. The objectives of the study were analysis of hemodynamic parameters, changes in the BIS Index, recovery characteristics, postoperative complications. Methods: Following IRB approval, an observational study was conducted in 60 patients of ASA grade I-II, aged 18-60 years undergoing surgical procedures under general anesthesia. Patients were randomly divided into two groups, with 30 patients each receiving propofol infusion (Group P) or sevoflurane (Group S) to maintain anesthesia. The requirement of anesthetic agents was titrated by BIS monitoring. BIS score was held between 40 to 60. Results: Hemodynamic parameters like heart rate and mean arterial pressure (MAP) were comparable in both groups. During recovery, the meantime to spontaneous ventilation, eye-opening, hand squeezing, following verbal command, extubation, stating the name, and mean time to achieve modified Aldrete's score of ≥ 9 from the cessation of the anesthetic drug was significantly shorter in Group S as compared to Group P. PONV was noted as a postoperative complication in the sevoflurane group. Conclusion: In our study, sevoflurane provided rapid emergence and faster recovery with stable hemodynamic. However, propofol appears to be an excellent alternative to sevoflurane for maintenance of anesthesia as it also provides fast recovery with a lower incidence of PONV