Abstract
For several decades, breast cancer (BC) undoubtedly ranks first in the structure of oncopathology and is the most common cause of the loss of working capacity of the female population in most countries. Considering the increasing quality of care for patients with breast cancer, there is the need for standardization and implementation of methods to assess not only quantitative but also qualitative component of a comprehensive opinion on the results of therapy. Therefore, an important indicator to be taken into account is the quality of life (QL) of a patient. Definition of QL of patients with inoperable forms of locally advanced breast cancer before and after neoadjuvant courses of systemic polychemotherapy (SPCT) and selective intra-arterial polychemotherapy in combination with systemic (SIAPCT). 154 patients with LA BC T4A-DN0-3M0, who received comprehensive treatment on the basis of the Donetsk regional antitumor center and the University clinic of the Odessa National Medical University during the period from 2000 to 2017, who received SPCT or SIAPCT as a neoadjuvant course, were included in the study. According to the quality of life during the treatment period, wavelike dynamics with a clear advantage of selective intra-arterial polychemotherapy over the system was observed. According to the quality of health between groups, the marginal statistically significant difference in favour of regional PCTs was formed. In a detailed study of each of the options found stable symptomatic scale dependent components of the integral index of quality of life on the severity and duration of intoxication syndrome. On the basis of the results obtained, the statistical advantage of the RMRM remains with the regional PCT. The QL study is a reliable, informative and economical method for assessing the health status of the patient, both at the group and at the individual level. In cancer studies, the evaluation of QL is an important criterion for assessing the effectiveness of treatment and has a prognostic value.
Highlights
During the last decades of the last century and at the beginning of the current cancer-registry of most countries have been continuously diagnosing breast cancer (BC) as the most common cancer and one of the most common causes of disability and mortality among the female population of the world [1]
The evaluation of quality of life (QL) is an important criterion for assessing the effectiveness of treatment and has a prognostic value
After completing 2 courses of chemotherapy, the QL score decreased in both groups by 11.1 % (46±4.3 points) in the first group, by 5.9 % (48±5.0 points) in the second, but the difference remained statistically insignificant
Summary
During the last decades of the last century and at the beginning of the current cancer-registry of most countries have been continuously diagnosing breast cancer (BC) as the most common cancer and one of the most common causes of disability and mortality among the female population of the world [1]. Despite the constant progress of medicine, new advances in the development of its general and special directions, as well as the tireless and close attention of the public to the problem of breast cancer, statistical data on a scale of decades do not show convincing qualitative changes in the dynamics of morbidity and mortality [4, 5]. All this naturally determines the need to increase the costs of maintaining and improving diagnostic, treatment and rehabilitation measures by insurance companies and the growing equity of clinical and academic interest in understanding the key aspects of BC [6, 7]
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