Abstract
The effect of correlation between the kinetics of acetylcholine (ACh) quanta release and the kinetics of the postsynaptic membrane channel activity on end-plate currents (EPCs) was studied in model experiments. The presynaptic process was described by a transmitter secretion probability distribution (SPD), and the postsynaptic process by characteristicsof miniature EPC (MEPC) with standard amplitude and variable decay duration (τMEPC). The SPD was represented by a curve with an S-like rise and exponential decay. The main portion of the data was analyzed after being adjusted to 20°C. The effect of the EPC amplitude loss (the difference between the EPC amplitudes in cases of synchronous and non-synchronous release of the ACh quanta) due to temporal dispersion of the transmitter secretion process was 43% at τMEPC=1.0 msec and 20% at τMEPC=4–5 msec under conditions when acetylcholinesterase (AChE) was inhibited.
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