Abstract
The aim of the present study was to compare the prognostic value of nestin-positive microvessel density (nestin+ MVD) to the CD34-positive (CD34+) MVD in patients with colorectal cancer. A total of 125 cases of colorectal cancer were used for the study. Immunohistochemical reactions were performed on paraffin sections using anti-nestin and anti-CD34. The average MVD was determined for both markers and was referenced to patients' clinicopathological data. A strong positive correlation was found between the MVDs for both analyzed antigens. Contrary to CD34+ MVD, a positive trend was observed between high nestin+ MVD and lymph node invasion. Moreover, significantly higher nestin+ MVD was noted in patients with more advanced clinical stage than in those with early-stage cancer. No such correlation was found for CD34 antigen. Additionally, a possible trend between the higher nestin+ MVD and shorter event-free survival was noted, whereas no such relation was observed for CD34+ MVD. The results suggest that nestin might be a reliable marker for angiogenesis evaluation in patients with colorectal cancer. In contrast to CD34, the expression of nestin in blood vessels seems to be a more sensitive marker of cancer progression.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
