Comparison of metabolic profile in between women with premature ovarian insufficiency and normal women

Abstract

Background: Premature ovarian insufficiency (POI) represents about 1percent among women who are in less than 40 years age group. It has great negative impact on psycho-social, sexual and overall, on the quality of life of women. Objective: This study was designed to investigate the comparison in lipid profiles, fasting blood sugar, systolic and diastolic blood pressure and waist circumference in between normal women and women with premature ovarian insufficiency (POI). Methods and materials: This was a cross-sectional comparative study. Fifty women (POI) were taken with purposive sampling as study group who were diagnosed as premature ovarian insufficiency of idiopathic cause from 18 to 40 years. 50 healthy women were taken as comparison group at the same age group. The study was done in the Obstetrics and Gynecology department of Z. H. Sikder Women’s Medical College, Dhaka from January 2020 to December 2021 over a period of two years. After taking written consent detailed information about the patients were collected in a predesigned data collection sheet for each patient. Metabolic syndrome (MS) was assessed for each one of POI. MS was diagnosed according the criteria of IDF (International diabetic federation). Results: Serum total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and fasting blood sugar were significantly higher and high-density lipoprotein cholesterol (HDL-C) was reduced in women with POI(p<0.05). There were no differences in triglycerides. Waist circumference was higher significantly in women with POI (p<0.05). Conclusion: Early cessation of ovarian function is related with higher levels of TC, LDL-C, fasting blood sugar and waist circumference and lower HDL-C. Women with POI have higher risk of metabolic syndrome. Early detection and lifelong management should be provided to avoid complications.