Comparison of long-term results between Hancock porcine bioprosthesis and Carpentier-Edwards pericardial bioprosthesis in the aortic and the mitral positions

Abstract

The aim of this study was to compare the long-term results with the Carpentier-Edwards pericardial bioprosthesis, a second-generation bioprosthesis, and the Hancock porcine valve in the aortic and mitral position. Long-term results of isolated valve replacement with the Carpentier-Edwards pericardial bioprosthesis (73 valves in the aortic position and 73 valves in the mitral position) were compared with those with the Hancock porcine bioprosthesis (41 valves in the aortic and 124 valves in the mitral position). In the aortic position, the mean follow-up period was 8.2±4.0 years with the Carpentier-Edwards pericardial bioprosthesis and 9.9±4.4 years with the Hancock porcine bioprosthesis. In the mitral position, the mean follow-up period was 7.5±4.3 years with the Carpentier-Edwards pericardial bioprosthesis and 10.0±5.3 years with the Hancock porcine bioprosthesis. The results showed that the mean age at implantation was significantly higher in patients with a Carpentier-Edwards pericardial bioprosthesis (58±13 years in the aortic and 51±15 years in the mitral) than in those with a Hancock bioprosthesis (42±13 years in the aortic and 45±10 years in the mitral). In the aortic position, actuarial freedom from structural deterioration of the Carpentier-Edwards pericardial bioprosthesis was significantly better (85±6% at 13 years) than that with the Hancock bioprosthesis (40±10%,P<0.02). In the mitral position, actuarial freedom from structural deterioration of the Carpentier-Edwards pericardial bioprosthesis was similar to that with the Hancock bioprosthesis (32±9% and 44±6% at 13 years, respectively). It is concluded that the durability of the Carpentier-Edwards pericardial bioprosthesis in the aortic position was satisfactory in the elderly patients. In the mitral position, the superior durability of the Carpentier-Edwards pericardial bioprosthesis against the Hancock bioprosthesis failed to be proved.