Abstract
Introduction: Present study was undertaken to compare the efficacy of intrathecal clonidine or buprenorphine with bupivacaine in lower abdominal surgeries.
 Methods:90 ASA I and II patients undergoing lower abdominal surgeries were randomly allocated into three groups(n=30). Group A received 3ml of 0.5% hyperbaric bupivacaine with 1ml normal saline, GroupB received 3ml of 0.5% hyperbaric bupivacaine with 60 mcg buprenorphine(1:5 dilution) and Group C received 3ml of 0.5% hyperbaric bupivacaine with 30mcg clonidine(1:5 dilution) respectively (Total volume 4ml). Onset time and duration of sensory and motor block, duration of analgesia, hemodynamics, VAS score, sedation score and side effect were compared.
 Results: The duration of analgesia was significantly longest in GroupC (354.50±38.48min), followed by Group B (277.10±25.47min) and Group A(131.50±20.15min) (p<0.001)
 Conclusion: On comparing the two drugs, Clonidine appears to be superior in terms of postoperative analgesia.
 Keywords: Clonidine, Buprenorphine, Intrathecal
Highlights
Present study was undertaken to compare the efficacy of intrathecal clonidine or buprenorphine with bupivacaine in lower abdominal surgeries
The duration of analgesia was significantly longest in GroupC (354.50±38.48min), followed by Group B (277.10±25.47min) and Group A(131.50±20.15min) (p
Various adjuvants have been used intrathecally to improve the quality and duration of spinal anaesthesia with better postoperative analgesia like epinephrine, neostigmine, midazolam, ketamine, fentanyl, buprenorphine, clonidine and dexmedetomidine.2With this background, this study was designed to compare the efficacy of intrathecal buprenorphine and clonidine with control group for onset and duration of sensory and motor block, duration of analgesia, sedation and to evaluate the side effects, if any
Summary
Present study was undertaken to compare the efficacy of intrathecal clonidine or buprenorphine with bupivacaine in lower abdominal surgeries. Onset time and duration of sensory and motor block, duration of analgesia, hemodynamics, VAS score, sedation score and side effect were compared. Pain as defined by the International Association for the study of Pain (ISAP) is an “an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage”.1Lower abdominal surgeries may be performed under regional (spinal or epidural) or general anaesthesia. Various adjuvants have been used intrathecally to improve the quality and duration of spinal anaesthesia with better postoperative analgesia like epinephrine, neostigmine, midazolam, ketamine, fentanyl, buprenorphine, clonidine and dexmedetomidine.2With this background, this study was designed to compare the efficacy of intrathecal buprenorphine and clonidine with control group for onset and duration of sensory and motor block, duration of analgesia, sedation and to evaluate the side effects, if any
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