Abstract
Introduction: Intravenous propofol is commonly used for induction of general anesthesia because it is smooth and rapid. Inhalational induction method is used in limited situations like absence of venous access and difficult intubation. Sevoflurane also produces rapid induction comparable to propofol. We conducted this study to compare induction time and quality of sevoflurane with that of propofol.
 Methods:Total 102 patient undergoing elective laparoscopic surgery were divided into Group S and Group P with 51 patient in each group. In group S patient were induced with Sevoflurane 8% via vital capacity induction method. In group P, patients were induced with injection propofol 1% with titrating dose. Induction time, hemodynamic changes and complications during induction, patient satisfaction and cost of induction were compared.
 Results: Induction was rapid in Group S (53.33±17.29s) compared to Group P (72.27±25.15s) (p=0.01). The heart rate and mean arterial pressure were stable in both groups upto one minute after induction. Hypotension occurred more in Group P than in Group S (47.05%vs.37.25%).Cough (9.80 %vs.5.88%) and excessive secretions (5.88%vs.0%) were common in Group S while apnea (3.92%vs5.88%) and involuntary movements(17.64% vs. 27.45%) were common in Group P. Patient satisfaction score was high in both the groups. Cost of induction was cheaper in Group S compared with Group P (1.6±0.54 $vs.1.9±0.43$).
 Conclusions: Vital capacity induction with 8% sevoflurane has rapid induction and cheaper as compared to intravenous induction with propofol in a titrating dose. Hemodynamic changes and complications were comparable in both the groups.
Highlights
Intravenous propofol is commonly used for induction of general anesthesia because it is smooth and rapid
The heart rate and mean arterial pressure were stable in both groups upto one minute after induction
Hemodynamic changes and complications were comparable in both the groups
Summary
Intravenous propofol is commonly used for induction of general anesthesia because it is smooth and rapid. Inhalational induction method is used in limited situations like absence of venous access and difficult intubation. Sevoflurane produces rapid induction comparable to propofol. Propofol is most commonly used intravenous anaesthetic agent for induction of general anaesthesia. It is popular because of its rapid and smooth induction. Its use in adults is limited to situations like absence of venous access and in cases of difficult airway. After the introduction of sevoflurane, use of inhalational induction has become popular in adults. It has smooth induction and results in complete recovery. Speed of induction and qualities are similar to that of propofol when used in high concentration with vital capacity induction (VCI) method. [1, 2]
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