Abstract
Endometrial cancer occupies the sixth place among oncological morbidity structure in women worldwide. The aim . To compare the expression levels of estrogene receptors – α and progesterone receptors, regulatory proteins p16 and p53, a marker of proliferation Ki-67 and the apoptotic degradation enzyme caspase-3, matrix metalloproteinase 9 (MMP 9) and its tissue inhibitor TIMP-1 in tumor and stromal cells of the invasive non-metastatic endometrioid endometrial carcinoma and also in invasive metastatic endometrioid endometrial carcinoma. Materials and methods: Immunohistochemical and morphometric study of invasive non-metastatic рТ 1-4 N 0 M x endometrioid endometrial carcinoma (n=56; age 42-83 years), invasive metastatic рТ 1-4 N 1-2 M x endometrioid endometrial carcinoma (n=30; age 48-79 years) was performed. Results: Statistically significantly higher expression level of estrogen receptor-α was detected in tumor cells of endometrioid endometrial carcinoma with metastasis to the regional lymph nodes in comparison with the expression level of these receptors in tumor cells of non-metastatic endometrioid endometrial carcinoma. The progesterone receptors expression levels in the tumor and stromal cells of invasive endometrioid endometrial carcinoma with metastasis to regional lymph nodes were lower in comparison with the corresponding expression levels of progesterone receptor in corresponding cells of non-metastatic endometrioid endometrial carcinoma. In stromal cells of endometrioid endometrial carcinoma with metastasis to the regional lymph nodes the expression level of caspase-3 was significantly lower too in comparison with the expression level of this enzyme in stromal cells of non-metastatic endometrioid endometrial carcinoma. In tumor and stromal cells of endometrioid endometrial carcinoma with metastasis to the regional lymph nodes the expression levels of MMP-9 and TIMP-1 are decreased significantly compared to the expression level of these markers in the respective cells of non-metastatic endometrioid endometrial carcinoma. Conclusions . The expression level of estrogen receptor-α in the tumor cells was higher, the expression level of caspase 3 in stromal cells was lower and the expression levels of progesterone receptors, MMP 9 and TIMP-1 in tumor and stromal cells were lower in metastatic endometrioid endometrial carcinoma compared to non-metastatic endometrioid endometrial carcinoma. The obtained data can be used for individual prediction of metastasis to regional lymph nodes in patients with endometrioid endometrial carcinoma.
Highlights
Ключевые слова: карцинома эндометрия, рецепторы эстрогена-α, рецепторы прогестерона, р53, р16, Ki-67, каспаза 3, матриксная металлопротеаза 9, тканевой ингибитор металлопротеазы-1
The progesterone receptors expression levels in the tumor and stromal cells of invasive endometrioid endometrial carcinoma with metastasis to regional lymph nodes were lower in comparison with the corresponding expression levels of progesterone receptor in corresponding cells of non-metastatic endometrioid endometrial carcinoma
In tumor and stromal cells of endometrioid endometrial carcinoma with metastasis to the regional lymph nodes the expression levels of MMP-9 and TIMP-1 are decreased significantly compared to the expression level of these markers in the respective cells of non-metastatic endometrioid endometrial carcinoma
Summary
Ключевые слова: карцинома эндометрия, рецепторы эстрогена-α, рецепторы прогестерона, р53, р16, Ki-67, каспаза 3, матриксная металлопротеаза 9, тканевой ингибитор металлопротеазы-1. В эндометриоидной аденокарциноме эндометрия с метастазами в регионарные лимфатические узлы статистически значимо снижены уровни экспрессии ММП 9 и ТИМП-1 в опухолевых и стромальных клетках в сравнении с уровнем экспрессии этих маркеров в соответствующих клетках неметастатической эндометриоидной аденокарциномы эндометрия.
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