Abstract
Background. This study compared results of a study undertaken using Australia’s general practice electronic health record database, MedicineInsight, to assess risk of urinary-tract infections with sodium glucose cotransporter 2 inhibitors (SGLT2) for diabetes, by undertaking the same study in a 10% random sample of data from the national Pharmaceutical Benefits Scheme data. Methods. Cohort studies were undertaken using deidentified data from the two national datasets. In each dataset, initiators of SGLT2 inhibitors were compared to initiators of dipeptidyl peptidase 4 (DPP-4) inhibitors in the period Jan 2012 to Sep 2015. The risk of urinary-tract infections (UTI) was assessed in six-month follow-up after initiation of SGLT2 and DPP-4. Results. There were 1,977 people in the SGLT2 and 1,964 people in the DPP-4 cohort (MedicineInsight data) and 3,120 in the SGLT2 and 12,359 in the DPP-4 cohort (10% PBS data). In both datasets, the risk of UTI after initiation of SGLT2 was not significantly increased in comparison to DPP-4 cohort (MedicineInsight: 3.6% versus 4.9%; aHR=0.90, 95% CI 0.66-1.24; PBS: 3.0% versus 3.9%; aHR=0.90, 95% CI 0.72-1.13, 10%). Conclusions. Comparison of MedicineInsight data to PBS national pharmacy data demonstrated highly comparable results for the specific study question. MedicineInsight is a reliable source of data that can be used for pharmacoepidemiological studies.
Highlights
In 2011, the Australian Government Department of Health funded NPS MedicineWise “to establish and manage a longitudinal general practice data platform to improve the post-marketing surveillance of medicine use in Australia and support quality improvement activities in general practices” [1].NPS MedicineWise began to introduce a database (MedicineInsight) from 2013 onwards, with the aim of establishing a database comprising electronic health records for postmarketing surveillance of medicines and devices
For Pharmaceutical Benefits Scheme sodium glucose cotransporter 2 inhibitors (SGLT2) (PBS) data we investigated only dispensing of urinary-tract infections (UTI) specific medicines as no diagnostic or encounter information was available
There were 1,977 people initiated on SGLT2 inhibitors in the MedicineInsight data and 3,120 in the PBS data
Summary
The prescribing date, type, dose, strength, quantity, and number of repeats are recorded as well as reason for prescribing. This has the potential to be a significant advance of existing Australian datasets for pharmacoepidemiological studies and health service research as the data include clinical information. This study compared results of a study undertaken using Australia’s general practice electronic health record database, MedicineInsight, to assess risk of urinary-tract infections with sodium glucose cotransporter 2 inhibitors (SGLT2) for diabetes, by undertaking the same study in a 10% random sample of data from the national Pharmaceutical Benefits Scheme data. Comparison of MedicineInsight data to PBS national pharmacy data demonstrated highly comparable results for the specific study question. MedicineInsight is a reliable source of data that can be used for pharmacoepidemiological studies
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