Abstract
ObjectivesTo compare two scanning protocols (free breathing versus breath-hold) for perfusion imaging using dynamic volume computed tomography (CT) and to evaluate their effects on image registration.Material and methodsForty patients underwent dynamic volume CT for pancreatic perfusion analysis and were randomly assigned to either a shallow-breathing (I) or breath-hold (II) group. Both dynamic CT protocols consisted of 17 low-dose volumetric scans. Rigid image registration was performed by using the volume with highest aortic attenuation as reference. All other volumes were visually matched with the pancreatic lesion serving as the volumetric region of interest. The overall demand for post-processing per patient was calculated as the median of three-dimensional vector lengths of all volumes in relation to the relative patient origin. The number of volumes not requiring registration was recorded per group.ResultsRegistration mismatch for groups I and II was 2.61 mm (SD, 1.57) and 4.95 mm (SD, 2.71), respectively (P < 0.005). Twenty-eight volumes in group I (8.2%) and 47 volumes in group II (14.1%) did not require manual registration (P = 0.014).ConclusionShallow breathing during dynamic volume CT scanning reduces the overall demand for motion correction and thus may be beneficial in perfusion imaging of the pancreasMain Messages• Shallow breathing during perfusion CT scanning reduces the overall demand for motion correction.• Shallow breathing may be beneficial in perfusion imaging of the pancreas.• Image registration is crucial for CT perfusion imaging.
Highlights
Abdominal perfusion imaging using computed tomography (CT) has gained considerable interest in oncology, especially as a tool for tissue characterisation, staging and monitoring treatment response to anti-angiogenesis drugs [1]
Registration mismatch for groups I and II was 2.61 mm (SD, 1.57) and 4.95 mm (SD, 2.71), respectively (P
Shallow breathing during dynamic volume CT scanning reduces the overall demand for motion correction and may be beneficial in perfusion imaging of the pancreas Main Messages
Summary
Abdominal perfusion imaging using computed tomography (CT) has gained considerable interest in oncology, especially as a tool for tissue characterisation, staging and monitoring treatment response to anti-angiogenesis drugs [1]. Insights Imaging (2012) 3:323–328 predominantly of anti-angiogenic drugs have been the key targets for abdominal perfusion CT [6,7,8,9]. The fundamental principle of perfusion CT is based on the temporal changes in tissue attenuation provided the target volume remains stationary in space. Motion during data acquisition in CT inevitably leads to artefacts which jeopardise accurate calculation of perfusion values and parameter maps, in abdominal CT where organ shift, deformation and displacement peak during the respiratory cycle. Anatomical mismatch between the multiple acquisitions inescapably results in inaccurate calculation of perfusion values [11]. Patients were excluded from analysis in several studies to avoid incorrect perfusion results [12, 13]
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