Abstract
Background: Thyroid cancers are common endocrine tumors with diverse medical and histological structures. During development/progression from normal to neoplastic cell, there is a gradual increase in the function/activity of proto-oncogenes, transcription factors and metastasis elements. The main objective of this study is to evaluate per-oxidation of lipid content, total oxidative stress, and the profile of homocysteine (and DNA damage) in the erythrocytes of thyroid carcinoma patients as compared with those of control subjects.
 Methods: All risk variables and biochemical analyses were quantitatively determined using standard methods.
 Results: A noteworthy increase in malondialdehyde, globulin, and DNA damage in thyroid carcinoma patients were repeatedly observed. In contrast, healthy individuals showed an increased level of HDL-C and total anti-oxidant response.
 Conclusion: It is suggested that these parameters have a pivotal role in the diagnostic process of determining thyroid carcinoma patients. Oxidized products of macromolecules in the blood of such patients impart major function in causing thyroid carcinoma disease.
Highlights
Among all malignant cancers, thyroid carcinoma is being witnessed in increasing cases in European countries, USA and Canada (Siti et al, 2015; Mancini et al, 2016; Valko et al, 2007)
One-way analysis of variance (ANOVA) calculation suggested that body mass index (BMI) was significantly higher (P
Our study demonstrated that BMI was significantly high in thyroid carcinoma patients compared to controls (p=0.0008)
Summary
Thyroid carcinoma is being witnessed in increasing cases in European countries, USA and Canada (Siti et al, 2015; Mancini et al, 2016; Valko et al, 2007). It is more aggressive and common in the 30-60 year age group. Oxidized products of macromolecules in the blood of such patients impart major function in causing thyroid carcinoma disease
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