Abstract
The inhibitory effects of blueberry leaves on the proliferation of adult T-cell leukemia (ATL) cell lines have previously been reported. A comparison of blueberry leaf extracts from different cultivars and seasonal variation were investigated regarding their effects on ATL cell line proliferation. The inhibitory effects of 80% ethanol leaf extracts from different blueberry cultivars collected from April to December in 2006 or 2008 were evaluated using two ATL cell lines. The bioactivities of leaf extracts of rabbit-eye blueberry (Vaccinium virgatum Aiton; RB species), southern highbush blueberry (V. spp.; SB species), northern highbush blueberry (V. corymbosum L.; NB species), and wild blueberry (V. bracteatum Thunb.; WB species) were compared. Of these, leaves of the RB species collected in December showed a significantly stronger inhibitory effect in both cell lines than the SB, NB, or WB species. These results suggest elevated biosynthesis of ATL-preventative bioactive compounds in the leaves of the RB species before the defoliation season.
Highlights
IntroductionAdult T-cell leukemia (ATL) occurs in a small population of individuals infected with human
Adult T-cell leukemia (ATL) occurs in a small population of individuals infected with humanT-cell leukemia virus type I (HTLV-I)
There are four species of blueberry: rabbit-eye blueberry (Vaccinium virgatum Aiton: RB species), southern highbush blueberry (V. spp.: SB species), northern highbush blueberry (V. corymbosum L.: NB species) and wild blueberry (V. bracteatum Thunb.: WB species), with several cultivars existing in each type
Summary
Adult T-cell leukemia (ATL) occurs in a small population of individuals infected with human. There are four species of blueberry: rabbit-eye blueberry (Vaccinium virgatum Aiton: RB species), southern highbush blueberry (V. spp.: SB species), northern highbush blueberry (V. corymbosum L.: NB species) and wild blueberry (V. bracteatum Thunb.: WB species), with several cultivars existing in each type. These species differ distinctly in cold resistance, height and fruit size [7].
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