Abstract
Corynebacterium parvum was compared with Freund's complete adjuvant (FCA) for potentiation of the rabbit immune response to beta-human chorionic gonadotropin linked to tetanus toxoid (beta-hCG-TT). With each adjuvant, antibodies to hCG were detected using passive hemagglutination. Higher antibody titers were produced by FCA-treated animals. The ability of antisera to beta-hCG-TT to neutralize the biological action of native hCG was determined by the rat uterine weight assay. Anti-beta-hCG-TT sera from C. parvum-treated rabbits were not significantly different (p greater than 0.10) from FCA potentiated anti-beta-hCG-TT sera in neutralizing hCG-induced uterine weight gain. C. parvum has potential for future application in active immunization studies of fertility regulation.
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