Abstract
Our research uses magnetic resonance imaging and statistical tools to compare patients with TEMPORAL LOBE EPILEPSY WITH AND WITHOUT hippocampal atrophy, SEARCHING FOR DIFFERENCES RELATED TO GREY AND WHITE MATTER ATROPHY.
Highlights
Several studies have explored patterns of grey (GM) and white matter (WM) atrophy in mesial temporal lobe epilepsy (MTLE) patients, fewer have compared side and presence of atrophy
Two control subjects were matched for each patient (258 total controls). 3D T1 weighted images were segmented into GM and WM tissues, according to a standard SPM12/CAT 12 protocol, which included: spatial normalization [MNI-152], tissue segmentation and smoothing, Quality control of image segmentation was automatically performed
We identified a more widespread pattern of WM atrophy in all groups, with larger clusters on left TLE. (Image 2)
Summary
Several studies have explored patterns of grey (GM) and white matter (WM) atrophy in mesial temporal lobe epilepsy (MTLE) patients, fewer have compared side and presence of atrophy. Comparison of cortical atrophy among patients with right, left, bilateral and without hippocampal atrophy temporal lobe epilepsy through voxel-based morphometry. Abstract Our research uses magnetic resonance imaging and statistical tools to compare patients with TEMPORAL LOBE EPILEPSY WITH AND WITHOUT hippocampal atrophy, SEARCHING FOR DIFFERENCES RELATED TO GREY AND WHITE MATTER ATROPHY.
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