Abstract
Cervical cancer is an issue of foremost importance globally, specifically affecting the developing nations. Significant advances have taken place with regard to diagnosis of cervical cancer, especially with screening. Appropriate screening measures can thus reduce the incidence of cervical cancer. The most desirable screening technique should be less invasive, easy to perform, cost-effective and cover a wide range of diagnostic icons. Manual liquid based cytology (MLBC) can be considered as one of the suitable technique for screening with the above-mentioned benefits. The aim of the current study was to compare two cervical screening techniques on the basis of different morphological parameters and staining parameters by using modified acetic acid Pap staining to see the possibility of reducing time economy involved in conventional Pap staining (CPS). The study was conducted on a total 88 cases and all were analyzed with both MLBC and CPS. Forty eight cases that were regarded as satisfactory on the basis of Bethesda system by both methods were further recruited for investigation. Their morphological parameters and staining quality were compared and scored according to a scoring system defined in the study. Quality indices was calculated for both staining procedures and smear techniques.
Highlights
Cervical cancer is one of the foremost public health concerns after the breast cancer
The aim of the current study was to compare two cervical screening techniques on the basis of different morphological parameters and staining parameters by using modified acetic acid Pap staining to see the possibility of reducing time economy involved in conventional Pap staining (CPS)
Diagnostic parameters Total 80 cases were selected for screening study and while performing Manual liquid based cytology (MLBC), membrane remained intact in 66 cases and was disrupted in rest of 14 cases
Summary
Cervical cancer is one of the foremost public health concerns after the breast cancer. Eighty-three percent of the global cervical cancer occurs in developing countries where its mortality rate is approximately 80% of 470,000 patients (Parkin et al, 2002). Cervical cancer causes 270,000 deaths globally per year, major portion of these mortalities belongs to underdeveloped countries (Ferlay et al, 2010). Cervical cancer can be prevented by primary as well as secondary measures. Secondary prevention through cytological examination has been the mainstay for early detection of cervical cancer (Nandini et al, 2012). Cytological examination could be very helpful for timely diagnosis of cervical cancer, but this preventive measure is not commonly practiced in developing countries due to scarcity of resources, technical personals and other facilities (Nandini et al, 2012). In Pakistan, the burden of disease is increased, cervical cancer is the 4th common cancer in Pakistani women with an age standardized incidence rate (ASIR) of 6.5 per 100,000 (Sardar et al, 2008)
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