Abstract
This study was aimed to assess the blood pressure influence of rocuronium drug under general anesthesia and compares it with atracurium drug. The study recruited 50 adult patients, divided in to two groups the rocuronium drug groups which included 25 patients and atracurium drug group which included 25 patients, age ranged from (18-60 years) of both sexes who were (ASAI and ASAII) patients undergoing (elective surgeries) in Baghdad education hospital during the period from (October 2019 to March 2020). Anesthesia was induced with using I.V. propofol drug (1.5-2.5 mg/kg), ketamine drug (0.5 mg/kg) or (2-3 mg/kg) propofol drug. For the endotreacheal tube, and facility of intubation injection muscle relaxation the rocuronium drug (0.6 mg/kg) or atracurium drug (0.5 mg/kg), for maintenance rocuronium drug (0.1-0.2 mg/kg). 60 sec. was used after administration of the relaxant, attempt of intubation. Next intubation, lungs were mechanically ventilated, monitored, blood pressure recorded and MAP after five minutes and every five minute for 15 minutes. The resulting P-value of MAP in Rocuronium drug groups and Atracuruim drug group at pre-operative was 0.811 which was non-significant (P> 0.05). While at induction it was 0.309 which was also non-significant (P> 0.05). After 1min it was 0.574 which was non-significant (P> 0.05). After 5min it was 0.321 which was non-significant. After 10 min it was 0.954 which was non-significant (P> 0.05). The blood pressure effected from rocuronium drug and atracurium drug are different under general anesthesia. The Atracurium drugs has less marked change in MAP. In healthy patients it maybe not be of importance, nevertheless it could be nonessential in patients with preexisting cerebral, cardiac diseases, hypertension or the elderly, but Rocuronium drug has a marked change in MAP. This could be cautiously in the patients with preexisting cardiac or cerebral pathology or elderly or hypertension. In conclusions the MAP was increased at induction of rocuronium drug and was decreased at induction of atracurium drug in this study.
Highlights
Anesthesia is an integral and vital part of modern medical practice, allowing for patients to safely and comfortably undergo various procedures, tests, and surgical operations
Two main classes of drugs are used to facilitate general anesthesia: inhalational anesthetics and intravenous anesthetics. These drugs are often used in combination to provide a balanced anesthetic [2]
The relationship among blood flow, pressure difference and resistance is described in Darcy's law
Summary
Anesthesia is an integral and vital part of modern medical practice, allowing for patients to safely and comfortably undergo various procedures, tests, and surgical operations. Two main classes of drugs are used to facilitate general anesthesia: inhalational anesthetics and intravenous anesthetics. These drugs are often used in combination to provide a balanced anesthetic [2]. Arterial pressure is normally tightly regulated to ensure adequate flow of blood to tissues whilst avoiding the harmful effects of high pressures on the vasculature and end-organs. Mean arterial pressure (MAP) is normally 65-100mmHg, with normal systolic and diastolic blood pressures between 120-140 mmHg and 70–90 mmHg, respectively. The relationship among blood flow, pressure difference and resistance is described in Darcy's law. This in turn can be used to determine SVR [3]
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